A study in The American Journal of Gastroenterology found that people who did not get heartburn symptom relief from standard treatments but did not have detectable reflux tended to experience more distress and have a poorer quality of life, while symptoms for those with diagnosed gastroesophageal reflux disease who did not respond to proton
Clinicians should advise patients taking domperidone for gastroparesis to inform their other heath care practitioners and check to ensure there are no interactions with other medications, writes ACG Past President Dr. David Johnson of the Eastern Virginia Medical School. An American College of Gastroenterology guideline states that gastroparesis patients who cannot take metoclopramide can use
A study found 17.7% of patients who had primary laparoscopic anti-reflux surgery experienced recurrent gastroesophageal reflux disease, researchers reported in the Journal of the American Medical Association. For patients who had recurrent reflux, 16.4% had a second surgery and 83.6% went on long-term anti-reflux medication. Study: 17.7% of patients get GERD after anti-reflux surgery
Fueling the fire of debate on PPI safety, a new observational study in BMJ Open found the use of proton pump inhibitors for at least a year was associated with a 51% higher risk of early death, compared with 31% among those treated for six months to a year and 17% for three- to six-month
“Data on risk of dementia from PPIs conflicts with earlier publications”
An NIH-supported study of 10,486 patients found no link between proton pump inhibitor use and patient risks for mild cognitive impairment, Alzheimer’s disease and dementia, based on patient-reported data of PPI use. The data, reported in the Journal of the American Geriatrics Society, contradict findings of two other recent studies. “The current findings do not
First-Of-Its-Kind Study Investigates Antidepressant as Treatment for Functional Heartburn
Nonerosive reflux disease is a difficult entity with little or no evidence of acid injury, but persistent symptoms attributed to acid reflux. Many of these patients do not respond to even very potent acid blockers. Well, a study in The American Journal of Gastroenterology found the antidepressant imipramine was no better than a placebo in
Is it reflux or not? Dr. Philip O. Katz discusses the dilemmas we face when people perceive ongoing reflux despite optimal medical management. See the webinar here.
Study lends a proposed pathway to the previously reported association between PPI use and heart disease
The previously reported association between PPI use and heart disease was just that…an association, not a cause and effect. Associations are the weakest form of science. However, researchers have found that long-term exposure to proton pump inhibitors led to faster aging of endothelial cells that line blood vessels by impairing the ability of the cells
Coffee consumption linked to lower risk of colorectal cancer but higher risk of GERD
Source: Coffee consumption linked to lower risk of colorectal cancer | CTV News A new U.S. study has found more evidence for the health-giving properties of coffee, finding that more than 2.5 cups of coffee a day can significantly decrease your risk of colorectal cancer. But we all know coffee increases symptomatic reflux. It seems
The biggest admitted downside of PPI therapy at their introduction was cost. With the advent of over-the-counter and generic PPI’s, cost took a back seat and many more patients were managed on chronic, long-term PPI’s with no real attempt to stop or decrease that therapy. Over the past several years, a number of potential adverse
