Researchers link risk of gestational diabetes and glucose intolerances to nonalcoholic fatty liver disease
A Canadian study in The American Journal of Gastroenterology showed that women with ultrasound evidence of nonalcoholic fatty liver disease (NAFLD) during their early pregnancy were more likely to develop gestational diabetes and dysglycemia in the second trimester of their pregnancy than those without NAFLD. The findings were based on 476 healthy women who underwent
“A lot of people are afraid of colonoscopies but very few studies have documented the reasons why,” according to James M. Church, MD, of the department of colorectal surgery at the Cleveland Clinic. “Colonoscopy screening is the best way to prevent colorectal cancer but people often do not make use of the test because they are afraid of it.
An analysis of eight studies found continuous endurance exercise, such as running or cycling, for more than two hours may lead to exercise-induced gastrointestinal syndrome, which includes gut injury and impaired gut function, researchers wrote in the journal Alimentary Pharmacology & Therapeutics. Prolonged vigorous exercise can cause a stress response that shuts down gut function,
A study in the Journal of Gastroenterology and Hepatology found a modified colorectal cancer screening tool that included body mass index led to improved risk prediction for advanced neoplasia. Researchers based the tool on the Asia Pacific Colorectal Screening score. See the abstract here. See the review article in Physician’s Briefing here.
Considerable interest has arisen in recent years regarding the role of the human microbiome in health and disease, including in inflammatory bowel disease (IBD) — a category of disease that includes ulcerative colitis and Crohn’s disease and is thought to result from the interplay between immune system alterations, environmental triggers, genetic factors, and the interaction
An NIH-supported study of 10,486 patients found no link between proton pump inhibitor use and patient risks for mild cognitive impairment, Alzheimer’s disease and dementia, based on patient-reported data of PPI use. The data, reported in the Journal of the American Geriatrics Society, contradict findings of two other recent studies. “The current findings do not
Triple-DAA Pill Offers HCV Retreatment Option A combination of three drugs that act directly to block hepatitis C (HCV) replication successfully cured most patients who had previously failed therapy with such agents, researchers reported. In two phase III trials, the investigational combination of sofosbuvir, velpatasvir, and voxilaprevir cleared the virus in 96% and 98% of
Infestation with benign parasitic worms is one possible explanation for the low incidence of autoimmune diseases and allergies in less developed countries and, conversely, for the sustained increase in such inflammatory conditions in more sanitized and hence “dewormed” industrialized societies. Joel V. Weinstock, MD, of Tufts Medical Center in Boston, writing in Nature in an article