Patients’ Perceptions of PPI Risks

A recent article shows patient safety concerns about PPI’s are common and strongly associated with attempts at discontinuation, with or without a provider’s recommendation. Patients at high risk for GI bleeding, who clearly benefit from PPI’s, were just as likely to have tried stopping PPI’s as others. Physicians should always discuss the risks and benefits

Up to 6 mos PPI therapy may not affect bone health

Research recently published in the seminal journal Gastroenterology failed to find evidence of alterations in key markers of bone formation and metabolism in postmenopausal women on PPI’s. The study examined calcium absorption, serum or urine mineral levels, parathyroid hormone, Vitamin D status, or bone-mineral density with 6 months of PPI therapy.   The prospective double-blind study

No single test identifies reflux as the etiology for extra-esophageal symptoms.

It is well recognized that reflux can be causal in subgroups of patients with chest and ENT symptoms like asthma, cough, hoarseness, sore throat, sinusitis, and ear pain. However, the possibility of reflux as the cause for a variety of ENT symptoms is both overestimated and often abused. In fact, the cause of extraesophageal symptoms

Reflux treatments reduce risk of esophageal cancer

GERD affects 10% to 20% of adults in Western populations and has been known to be an increased risk factor for esophageal adenocarcinoma. Research on the association between antireflux medication or surgery and risk for esophageal adenocarcinoma has remained limited, although the typical approach has been to treat reflux aggressively when there are precancerous changes like

Long-term PPI use no greater risk for Alzheimer’s patients

Several articles have shown an increased risk of fractures with PPI use as patients get older. Sanna Torvinen-Kiiskinen, PhD, of Kuopio Research Centre of Geriatric Care at the University of Eastern Finland, and colleagues wrote that an association between proton pump inhibitor (PPI) use and risk for fractures remains unclear due to contradictory study findings, and

Evidence for risks of PPI is weak

Experts say even though studies have linked proton pump inhibitor use to multiple health problems, the scientific evidence overall is weak, which should help providers reassure concerned patients and avoid unnecessary discontinuation of PPI use. The attention on PPI safety, however, does offer an opportunity for practitioners to discuss limiting use of the drugs because

GERD linked to head and neck cancer risk

According to a study published online Dec. 21 in JAMA Otolaryngology-Head & Neck Surgery, data for 13,805 patients aged 66 and older found that gastroesophageal reflux disease was linked to an increased risk of malignancy of the larynx, oropharynx, hypopharynx, tonsil, nasopharynx and paranasal sinuses. “GERD is associated with the presence of malignancy of the (upper aerodigestive

Large study links moderate coffee consumption to health benefits

Drinking coffee might reduce the risks for cardiovascular disease, cardiovascular mortality and all-cause mortality in most people, but those benefits wane after about three cups a day, according to a review of 218 meta-analyses published in The BMJ. Coffee consumption was linked to lower rates of liver disease, diabetes and some cancers; however, the researchers

GERD symptoms tied to psychological factors

  A study in The American Journal of Gastroenterology found that people who did not get heartburn symptom relief from standard treatments but did not have detectable reflux tended to experience more distress and have a poorer quality of life, while symptoms for those with diagnosed gastroesophageal reflux disease who did not respond to proton