Healthy adults had less bloating, increased well-being, and a small but significant weight loss on low-gluten compared with high-gluten diets, a study published in Nature Communications found. However, the study found those benefits may be linked to the diet’s dietary fiber rather than lack of gluten. “Gluten-free may not necessarily be the healthy choice many
A meta-analysis and review of available supportive therapies for IBS finds that antidepressants are efficacious in reducing symptoms in IBS patients. Psychological therapies also appear to be effective treatments for IBS, although there are limitations in the quality of the evidence, and treatment effects may be overestimated as a result. See the paper here.
Yes, that title leads to all kinds of imagery! “Leaky gut syndrome” is a hypothetical condition that is believed to cause chronic inflammation throughout the body and may result in a wide range of conditions. Proposed sequelae include chronic fatigue syndrome, rheumatoid arthritis, lupus, migraines, multiple sclerosis, and autism. The proposed mechanism is that the intestinal
An association between celiac disease and microscopic colitis has long been recognized. A study published in The American Journal of Gastroenterology explored the possibility of non-celiac sensitivity to gluten. The results suggested eating a diet that contains gluten did not increase the risk for microscopic colitis in women who do not already have celiac disease. See
Identifying biomarkers and symptoms will allow doctors to shorten the length of time it takes to find an effective treatment for IBS patients, writes Dr. William Chey of Michigan Medicine. IBS is not a single disease but likely is several issues that have similar symptoms, Chey writes. Unfortunately, no reliable markers which distinguish the subtypes
Celiac disease patients experience higher rates of functional dyspepsia, according to a study in The American Journal of Gastroenterology. Researchers also found an association between self-diagnosed wheat sensitivity (with no history of celiac disease, inflammatory bowel disease, or colorectal cancer) and irritable bowel syndrome. See the article on Clinical Advisor here.
Nobel Prize winning gastroenterologist Barry Marshall discusses research in which the diagnosis of IBS may be made with bowel sound analysis. The underlying processes which lead to symptoms of IBS are well studied, well characterized, but not well understood in their entirety. Abnormalities of perception, gut rhythm, stool production, the microbiome, and the neuroendocrine system
Researchers conclude that fecal profiling of volatile organic compounds (VOC’s) may provide a low cost, non-invasive tool to predict the responses of irritable bowel syndrome (IBS) patients to probiotics and diets low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP’s). Modeling baseline fecal VOC’s, and using key features of VOC profiles, correctly predicted response to
Symptoms meeting the Rome IV criteria for functional dyspepsia were found in 12% of US adults and 8% of people in the UK and Canada, researchers reported in The Lancet Gastroenterology & Hepatology. The most common subtypes were postprandial distress syndrome, epigastric pain syndrome and both syndromes together. These individuals had more-impaired health and used more
The FDA sent letters to manufacturers of loperamide, a longstanding and commonly used treatment for diarrhea, asking them to change the size of the drug’s packaging to limit the amount of opioid drugs in the package. The agency aims to discontinue the large bottles in which loperamide is often sold to deter its abuse. See