The previously reported association between PPI use and heart disease was just that…an association, not a cause and effect. Associations are the weakest form of science. However, researchers have found that long-term exposure to proton pump inhibitors led to faster aging of endothelial cells that line blood vessels by impairing the ability of the cells to produce enough acid to clear waste. This aging effect might hamper the cells’ ability to protect blood vessels from disease which could lead to heart attack and stroke. This still isn’t a nail in the coffin of PPI’s. But, this isn’t good news for the many millions of PPI users throughout the world.
Source: Clues to How Popular Heartburn Drug Might Harm Arteries