Proton pump inhibitor therapy is not connected to an increased risk of cardiovascular disease, according to a study published in Alimentary Pharmacology & Therapeutics. The FDA has discouraged using PPI’s with antiplatelet therapy clopidogrel because the drugs work with the same isoenzyme. “Inhibition of CYP2C19 by PPIs may reduce the bioavailability of the active metabolites of
Patients with detectable fecal hemoglobin or a positive guaiac fecal occult blood test result face a higher risk of dying from colorectal cancer, compared with those who had a negative test result, according to a study in Gut. This is as expected, as blood in the stool is a well-known sign of potential colon cancer.
Identifying biomarkers and symptoms will allow doctors to shorten the length of time it takes to find an effective treatment for IBS patients, writes Dr. William Chey of Michigan Medicine. IBS is not a single disease but likely is several issues that have similar symptoms, Chey writes. Unfortunately, no reliable markers which distinguish the subtypes
From the AGA website, here is a nice review of the data thus far and how to alleviate your patients’ concerns. See the AGA review here.
Having an anesthesiologist hand off care and leave during the middle of a surgery was associated with worse outcomes for the patient on the operating table. Combined mortality, hospital readmission, and major complications within 30 days after the operation reached a rate of 44% when a handover between anesthesiologists occurred during surgery versus 29% when
Experts say even though studies have linked proton pump inhibitor use to multiple health problems, the scientific evidence overall is weak, which should help providers reassure concerned patients and avoid unnecessary discontinuation of PPI use. The attention on PPI safety, however, does offer an opportunity for practitioners to discuss limiting use of the drugs because
The use of artificial intelligence can increase the accuracy and sensitivity of adenoma detection during colonoscopy, even for small lesions, a new study shows. The results were discussed by Dr. William Karnes of the University of California at Irvine at the World Congress of Gastroenterology at ACG 2017. Dr. Yuichi Mori of Showa University in
Drinking coffee might reduce the risks for cardiovascular disease, cardiovascular mortality and all-cause mortality in most people, but those benefits wane after about three cups a day, according to a review of 218 meta-analyses published in The BMJ. Coffee consumption was linked to lower rates of liver disease, diabetes and some cancers; however, the researchers
A longitudinal study in the American Journal of Gastroenterology found that elevated peripheral blood eosinophils found in the white-cell differential of blood tests might better predict the severity of inflammatory bowel disease in a subgroup of patients. “These results are very important, as we are always searching for predictors of more severe disease in order
Shared inflammatory pathways and genetics may predispose patients with respiratory conditions to developing IBD Ever-mounting evidence is strengthening the link between inflammatory bowel disease (IBD) and immune-mediated respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Research has suggested that IBD and airway illnesses likely share common inflammatory pathways as well as predisposing
