Celiac disease linked to many other medical conditions

An analysis of the Explorys database, which contains EHR data from 26 major US health care systems, linked celiac disease with a range of medical conditions, including gastroesophageal reflux disease, pancreatitis, colitis and autism, researchers reported at the World Congress of Gastroenterology at ACG2017.

The rate of celiac disease is almost 20 times higher in people with autism than in those without, for example, reported lead investigator Daniel Karb, MD, a second-year resident at University Hospitals Case Medical Center in Cleveland.

He and his colleagues searched the Explorys database, which aggregates electronic health record data from 26 major integrated healthcare systems in the United States. Of 35,854,260 people in the database, 83,090 were diagnosed with celiac disease from 2012 to 2017. The overall celiac disease rate was 0.22%.

Prevalence of Diagnoses in People With and Without Celiac Disease (P < .0001 for All)

Diagnosis With Celiac Disease, % Without Celiac Disease, % Odds Ratio
Migraine 18.6 4.1 5.5
Anxiety disorder 25.9 8.7 4.0
Arthritis 28.9 8.4 4.9
Dermatitis herpetiformis 1.3 0.0 4563.5
Liver disease 23.2 4.2 7.1
Gastroesophageal reflux disease 36.8 13.0 4.5
Eosinophilic esophagitis 0.6 0.1 8.8
Atrophic gastritis 3.9 0.1 8.0
Glossitis 0.4 0.1 4.4
Pancreatitis 15.8 0.7 25.0
Disorder of the pancreas 17.2 1.1 19.0
Cerebellar ataxia 0.1 0.0 4.1
Autism 4.0 0.2 19.9
Colitis 25.9 4.2 8.4
Turner syndrome 0.1 0 17.8
Down syndrome 0.6 0.1 8.1
Common variable immunodeficiency 0.2 0.0 10.2

 

See the full review article on Medscape here. 

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