Identifying biomarkers and symptoms will allow doctors to shorten the length of time it takes to find an effective treatment for IBS patients, writes Dr. William Chey of Michigan Medicine. IBS is not a single disease but likely is several issues that have similar symptoms, Chey writes. Unfortunately, no reliable markers which distinguish the subtypes
Nobel Prize winning gastroenterologist Barry Marshall discusses research in which the diagnosis of IBS may be made with bowel sound analysis. The underlying processes which lead to symptoms of IBS are well studied, well characterized, but not well understood in their entirety. Abnormalities of perception, gut rhythm, stool production, the microbiome, and the neuroendocrine system
An article appearing in Nature suggested that a common food additive known as trehalose might be responsible for the current Clostridium difficile epidemic. The Nature paper shows us that two of the most virulent strains of C. diff, including the “hypervirulent” ribotype 027, can metabolize even trace amounts of trehalose. They go on to show that when strains are mixed together, low
A new study shows a product based on activated charcoal protects the gut microbiome in patients taking antibiotics. The Phase I clinical trial showed promising results. The study reported in the Journal of Infectious Diseases compared DAV132, with a placebo. “DAV132 was highly effective to protect the gut microbiome of moxafloxacin-treated healthy volunteers and may
Consuming 2 to 3 cups of homemade yogurt daily led to a remission of IBS in 89% of participants in a study at two medical centers in eastern Kentucky presented at the World Congress of Gastroenterology at ACG2017. Although some study designs were noted, the experiment showed promise. See the review on Medscape here.
A low FODMAP diet was more effective at improving symptoms than general dietary advice (GDA) in a study published in the Journal of Gastroenterology and Hepatology. Gastrointestinal symptoms , stool frequency, and consistency improved after six weeks in the FODMAP group. However, both groups experienced reductions in symptom severity, abdominal pain, distension, consistency and frequency.
Patients with higher levels of Tannerella forsythia bacteria, which can be associated with gum disease, may have a greater risk of esophageal cancer. The increase may be as much as 21% according to a study in Cancer Research. Other bacteria, for example Streptococcus and Neisseria bacteria, were linked to decreased risk. “Our study indicates that
The contribution of environmental factors, diet, and related issues like the status of the microbiome once again come into focus in a recent medical article. A Canadian study in The American Journal of Gastroenterology linked living in a rural area with a lower risk of inflammatory bowel disease. The protective effect was particularly strong among
Link Between Antibiotics and IBD Remains Circumstantial Effect stronger in children, and underscores need for antibiotic stewardship in prescribing for pediatric infections Since inflammatory bowel disease (IBD) is linked to disruption of the intestinal microbiome, antibiotics have come under increasing scrutiny as possible environmental catalysts in IBD – especially if taken in early childhood. So
Researchers at the University of California, Davis found that chronic liver inflammation is associated with a Western diet via the type of bacteria present in the gut. “We know the transition from steatosis, or fatty liver, to steatohepatitis (inflammation in the fatty liver) plays a crucial role in liver injury and carcinogenesis,” Yu-Jui Yvonne Wan, professor
