A study in JAMA Network Open found that higher AST to ALT liver enzyme ratios, reduced ALT levels, and higher alkaline phosphatase readings were associated with Alzheimer’s disease. Specific markers such as poor cognition, elevated amyloid-beta accumulation, increased brain atrophy, and lower brain glucose metabolism were noted. The findings were based on PET, MRI, and cerebrospinal fluid data involving 1,581 older adults. The researchers suggested the role of liver functioning in Alzheimer’s pathogenesis.
