Clinicians should advise patients taking domperidone for gastroparesis to inform their other heath care practitioners and check to ensure there are no interactions with other medications, writes ACG Past President Dr. David Johnson of the Eastern Virginia Medical School. An American College of Gastroenterology guideline states that gastroparesis patients who cannot take metoclopramide can use domperidone when prescribed with FDA investigational new drug clearance, although the drug is not approved in the US. Risks include cardiac arrhythmias, cardiac arrest and sudden death.